Hesham Fahmy

Hesham Fahmy

Associate Professor

Education

  • B.S. in pharmacy
  • M.S. in pharmaceutical chemistry
  • Ph.D. in medicinal chemistry

Academic and Professional Experience

Academic Interests
Academic Interests
  • Medicinal chemistry
  • Drug design
  • Synthetic organic chemistry
  • Natural products
Academic Responsibilities
  • Medicinal Chemistry I (PHA 340)
  • Medicinal Chemistry II (PHA 341)
  • Pharmacology (PHA 453)
  • Advanced Concepts in Medicinal Chemistry (PHA 725)
  • Introduction to Drug Discovery (PHA 720)
  • Techniques in Pharmaceutical Sciences (PHA 746)
Committees and Professional Memberships
  • College Curriculum Committee
  • Curricular Progression and Variation Committee
  • College Assessment Committee

Research and Scholarly Work

Areas of Research
  • Design and synthesis of Corticotropin-releasing factor receptor antagonists
  • Design and synthesis of T-/L-types calcium channel blockers
  • Semi-synthetic natural products of medicinal interest
  • Skin cancer chemoprevention
  • Marine natural products of medicinal interest
Patents
  • Salvinorin Derivatives with Selective k-Opioid Receptor Affinity, Zjawiony, J.K., Fahmy, H.; Stewart, J.; Roth, B.: PCT Int. Appl. WO 2006012643, A2 20060202 (2006), C.A. 144, 164284 (2006)
  • Cembranoids of Chemopreventive Activity. Zjawiony, J.K., Fahmy, H., Katsuyama, I., Khalifa, S., Konoshima, T.: PCT Int. Appl. WO 2003095404, A1 20031120 (2003), C.A. 139, 381637 (2003).
Publications
  1. Design, Synthesis and Biological Evaluations of Novel Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor Receptor Antagonists as Potential Treatments for Stress Related Disorders and Congenital Adrenal Hyperplasia, Md Rabiul Islam, Christos Markatos, Ioannis Pirmettis, Minas Papadopoulos, Vlasios Karageorgos, George Liapakis and Hesham Fahmy, Molecules, 29, 3647, 1-24, (2024)
  2. Non-small cell lung cancer sensitization to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors, Hassan Gamal, Khadiga a. ismail, A-Mohsen M.E. Omar, Mohamed Teleb, Marwa M. Abu-serie, Sun Huang, Abdalla S. Abdelsattar, Gerald W. Zamponi and Hesham Fahmy, Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 39, No. 1, 2388209, 1-22, (2024)
  3. Design, synthesis, structural optimization, SAR, in silico prediction of physicochemical properties and pharmacological evaluation of novel and potent thiazolo[4,5-d]pyrimidine corticotropin releasing factor receptor antagonists: Md Rabiul Islam, Mohamed Teleb, Vlasios Karageorgos, Stelios Sakellaris, Minas Papadopoulos, Ioannis Pirmettis, Frank R. Fronczek, George Liapakis, Hesham Fahmy, European Journal of Pharmaceutical Sciences 169, 106084 (2022)
  4. Thiazolopyrimidine Scaffold as a Promising Nucleus for Developing Anticancer Drugs: a Review in Last Decade: Md Rabiul Islam and Hesham Fahmy, Anticancer Agents in Medicinal Chemistry, 22(17):2942-2955 (2022)
  5. Structural optimization, synthesis and in vitro synergistic anticancer activities of combinations of new N3-substituted dihydropyrimidine calcium channel blockers with cisplatin and etoposide: Marwa H. El-Wakil, Mohamed Teleb, Marwa.M. Abu-Serie, Sun Huang, Gerald W. Zamponi, Hesham Fahmy, Bioorganic Chemistry, 115, 105262 (2021)
  6. Design, synthesis and pharmacological evaluation of some substituted dihydropyrimidines with L-/T-type calcium channel blocking activities: Mohamed Teleb, Ola H. Rizk, Fang-Xiong Zhang, Frank R. Fronczek, Gerald W. Zamponi, Hesham Fahmy, Bioorganic Chemistry, 83 354-366 (2019)
  7. Selective antagonism of CRF1 receptor by a substituted pyrimidine, Stelios Sakellaris, Minos-Timotheos Matsoukas, Vlasios Karageorgos, Smaragda Poulaki, Bhimanna Kuppast, Andrew Margioris, Maria Venihaki, Hesham Fahmy, George Liapakis. Hormones, International Journal of Endocrinology and Metabolism, 18(2), 215-221 (2019)
  8. Synthesis of some new C2 substituted dihydropyrimidines and their electrophysiological evaluation as L-/T-type Calcium Channel blockers: Mohamed Teleb, Ola H. Rizk, Fang-Xiong Zhang, Frank R. Fronczek, Gerald W. Zamponi, Hesham Fahmy, Bioorganic Chemistry, 88, 102915 (2019)
  9. Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor antagonists: Mohamed Teleb, Katerina Spyridaki, George Liapakis, Hesham Fahmy. European Journal of Medicinal Chemistry, 138, 900-908 (2017)
  10. Synthesis of Novel N3-substituted Dihydropyrimidine Derivatives as L-/T- Type Calcium Channel Blockers, Mohamed Teleb, Fang-Xiong Zhang, Ahmed M. Farghaly, Omaima M. Aboul Wafa, Frank R. Fronczek, Gerald W. Zamponi and Hesham Fahmy. European Journal of Medicinal Chemistry 134, 52-61 (2017)
  11. Synthesis and Biological Evaluation of Novel N3-substituted Dihydropyrimidine Derivatives as T-Type Calcium Channel Blockers and Their Efficacy as Analgesics in Mouse Models of Inflammatory Pain, Mohamed Teleb, Fang-Xiong Zhang, Junting Huang, Vinicius M Gadotti, Ahmed M. Farghaly, Omaima M. Aboul Wafa, Gerald W. Zamponi and Hesham Fahmy. Bioorganic and Medicinal Chemistry 25, 1926-1938 (2017)
  12. A comprehensive review in development of thiazolo[5,4-d]pyrimidines based molecules in medicinal chemistry, Bhimanna Kuppast, Mohamed Teleb, Hesham Fahmy, Jacob Journal of Medicinal Chemistry, 2(1), 008 (2017)
  13. Structure and Function of Small Non-Peptide CRF Antagonists and their Potential Clinical Use, Fahmy, H., Kuppast, B., Ismail, M.; Current Molecular Pharmacology: 10, 270-283 (2017)
  14. Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery. Kuppast, B. and Fahmy, H.: European Journal of Medicinal Chemistry, 113, 198-213 (2016)
  15. Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators. Kuppast, B., Spyridaki, K., Lynch, C., Hu, Y., Liapakis, G., Davies, G., Fahmy, H., Medicinal Chemistry (Impact factor 1.38), 11, 50-59 (2015).
  16. Evaluation of the anti-melanoma activities of (1S,2E,4R,6E,8R,11S,12R)-8,12-epoxy-2,6-cembradiene-4,11-diol, (1S,2E,4R,6E,8S,11R,12S)-8,11-epoxy-4,12-epoxy-2,6-cembradiene and (1S,4R,13S)-cembra-2E,7E,11E-trien-4,13-diol from the Red Sea soft coral Sarcophyton glaucum. Szymanski, P., Ahmed, S., Radwan, M., Khalifa, S. and Fahmy, H., Natural Products Communication; 9(8), 1143-1146 (2014).
  17. Evaluation of the antimelanoma activities of Sarcophine, (+)-7伪,8 尾 Dihydroxydeepoxy sarcophine and Sarcophytolide from the Red Sea soft coral Sarcophyton glaucum. Pawel T. Szymanski, Safwat A. Ahmed, Mohamed M. Radwan, Sherief I. Khalifa and Hesham Fahmy, Natural Products Communication; 9 (2), 151-154 (2014)
  18. Synthesis of new substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands. Bhimanna Kuppast, Katrina Spyridaki, George Liapakis, Hesham Fahmy, European Journal of Medicinal Chemistry, 78, 1-9 (2014)
  19. Chemopreventive Effect of Sarcophine-diol on NOR-1-Induced TPA-Promoted Skin Carcinogenesis in Female HOS:HR-1 Mice. Pawel T. Szymanski, Safwat A. Ahmed, Sherief Khalifa, Harukuni Tokuda, Eiichiro Ichiishi, Akira Iida, Nobutaka Suzuki and Hesham Fahmy. Natural Products Communication, 8 (2), 153-154 (2013)
  20. Bioactive cembranoids from the Red Sea soft coral Sarcophyton glaucum. Rania F. Abou El-Ezz, Safwat A. Ahmed, Mohamed M. Radwan, Nahla A. Ayoub, Manal S. Afifi, Samir A. Ross, Pawel Szymanski, Hesham Fahmy, Sherief I. Khalifa. Tetrahedron Letters, 54, 989-992 (2013)
  21. Chemopreventive effects of combination of honokiol and magnolol with alpha- santalol on skin cancer development. Chilampalli, C.; Zhang, X.; Kaushik, R.S.; Young, A.; Zeman, D.; Hildreth, M.B.; Fahmy, H.;  Dwivedi, C.: Drug Discoveries and Therapeutics, 7(3), 109-115 (2013)
  22. Sarcophine-Diol Inhibits Expression of COX-2, Inhibits Activity of cPLA2, Enhances Degradation of PLA2 and PLC纬1 and Inhibits Cell Membrane Permeability in Mouse Melanoma B16F10 Cells. Szymanski, P., Muley, P., Ahmed, S., Khalifa, S., Fahmy, H.: Marine Drugs, 10, 2166-2180 (2012).
  23. The 鈥渉omeostasis hormone鈥 and its CRF1 receptor. From structure to function. Fahmy, H., Spyridaki, K., Kuppast, B., Liapakis, G.: Hormones, 11(3):254-271 (2012).
  24. Sarcophine-Diol, a Skin Cancer Chemopreventive Agent, Inhibits Proliferation and Stimulates Apoptosis in Mouse Melanoma B16F10 Cell Line. Szymanski, T., Kuppast, B., Ahmed, A., Khalifa, S., Fahmy, H.: Marine Drugs, 10, 1-19 (2012).
  25. Dose-response on the chemopreventic effects of sarcophine-diol on UVB-induced skin tumor development in SKH-1 hairless mice. Guillermo, R.F., Zhang, X., Kaushik, R.S., Zeman, D., Ahmed, S., Khalifa, S., Fahmy, H., Dwivedi, C.: Marine Drugs, 10, 2111-2125; (2012).
  26. Time and dose-response effects of honokiol on UVB-induced skin cancer development. Guillermo, R.F., Chilampalli, C., Zhang, X., Zeman, D., Fahmy, H., and Dwivedi, C.: Drug Discoveries and Therapeutics, 6:140-146 (2012).
  27. Chemopreventive effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action. Chilampalli, C., Guillermo, R., Zhang, X., Kaushik, R.S., Young, A., Zeman, D., Hildreth, M., Fahmy, H., Dwivedi, C.: BMC Cancer, 11:456 (2011).
  28. Honokiol, a chemopreventive agent against skin cancer induces cell cycle arrest and apoptosis in human epidermoid A431 cells. Chilampalli, C., Guillermo,R. , Kaushik, R., Young, A.,  Chandrasekher, G., Fahmy, H., Dwivedi, C.: Experimental Biology and Medicine, 1-9 (2011).
  29. Inhibitory effect and transcriptional impact of berberine and evodiamine on human white preadipocyte differentiation. Hu, Y., Fahmy, H., Zjawiony, J., Davies, G.: Fitoterapia, 81(4), 259-268 (2010).
  30. Alpha-santalol, a chemopreventive agent against skin cancer, causes G2/M cell cycle arrest in both p53-mutated human epidermoid carcinoma A431 cells and p53 wild-type human melanoma UACC-62 cells. Zhang X, Chen W, Guillermo R, Chandrasekher G, Kaushik RS, Young A, Fahmy H, Dwivedi C.: BMC Res Notes, 3, 3:22 (2010).
  31. Chemopreventive Effects of Honokiol on UVB-induced Skin Cancer Development. Chilampalli, C., Zhang, X., Fahmy, H., Kaushik, R., Zeman, D., Hildreth, M., Dwivedi, C.: Anticancer Research, 30, 777-784 (2010).
  32. Synthesis and biological evaluation of some thiazolylpyrazole derivatives as dual anti-inflammatory and antimicrobial agents. Bekhit, A. Fahmy, H., Rostom, S., Bekhit, A.A.: European Journal of Medicinal Chemistry, 45 6027-6038 (2010).
  33. Chemopreventive Effects of Sarcophine-diol on Ultraviolet Binduced Skin Tumor Development in SKH-1 Hairless Mice. Zhang, X., Bommareddy, A., Chen, W., Hildreth, M. B., Kaushik, R., Zeman, D., Khalifa, S., Fahmy, H., Dwivedi, C.: Marine Drugs (Impact Factor 3.85), 7, 153-165 (2009).
  34. Sarcophine-diol, a chemopreventive agent of skin cancer, inhibits cell growth and induces apoptosis through extrinsic pathway in human epidermoid carcinoma A431 cells. Zhang, X., Bommareddy, A., Chen, W., Khalifa, S., Kaushik, R., Fahmy, H., Dwivedi, C.: Translational Oncology, 2(1), 21-30 (2009).
  35. Synthesis of somesulfonamides, disubstituted sulfonylureas or thioureas and some structurally related variants. A class of promising antitumor agents. Faidallah, H.M., Al-Saadi, M. S., Rostom, S. A. F. and Fahmy, H.: Medicinal Chemistry Research, 16, 300-318 (2008).
  36. Effects of Sarcophine-diol in Human Epidermoid Carcinoma A431 Cells and its Possible Mechanism of Action. Zhang, X., Schrader, D., Kundoor, V., Khalifa, S., Zeman, D., Fahmy, H., Dwivedi, C.: Cancer Letters, 253, 53-59 (2007).
  37. Chemopreventive Effects of Sacrotriol in Ultraviolet B-Induced Skin Tumor Develiopment in SKH-1 Hairless Mice. Kundoor, V., Zhang, X., Bommareddy, A., Khalifa, S., Fahmy, H., Dwevedi, C.: Marine Drugs, 5, 197-207 (2007).
  38. Synthesis of Novel Benzofuran and Related Benzimidazole Derivative for Evaluation of in vitro Anti-HIV-1, Anticancer, and Antimicrobial Activities. Rida, S., El-Hawash, S., Fahmy, H., Hazza, A., El-Meligy, M.: Arch Pharm Res, 29(10), 826-833 (2006).
  39. A Possible Mechanism of  Action of the Chemopreventive Effects of Sarcotriol on Skin Tumor Development in CD-1 Mice. Kundoor, V., Zhang, X., Khalifa, S., Fahmy, H., Dwivedi, C.: Marine Drugs, 4, 274-285 (2006).
  40. Potent Skin Cancer Chemopreventive Activity of Some Novel Semi-synthetic Cembranoids from Marine Sources. Fahmy, H., Zjawiony, J., Konoshima, K., Tokuda, H., Khan, S., Khalifa, S.: Marine Drugs, 4, 28-36 (2006).
  41. Salvinorin A, a Potent and Selective Kappa-Opoid Receptor Agonist. Stewart, J., Fahmy, H., Roth, B., Yan, F., Zjawiony, J. Bioisosteric Modification of Arzneim Forsch. Drug Res. 56(4), 269-275 (2006).
  42. Synthesis and in vitro Evaluation of Some Novel Benzofuran Derivatives as Potential Anti-HIV-1, Anticancer and Antimicrobial Agents. Rida, S., El-Hawash, S., Fahmy, H., Hazza, A., El-Meligy, M. Acrch Pharm Res., 29(1), 16-25 (2006).
  43. An Improved Synthesis of  7,8-Epoxy-1,3,11-cembratriene-15R(伪),16-diol,A Cembranoid of Marine Origin With a Potent Cancer Chemopreventive Activity.
    Fahmy, H., Khalifa, S. I., Konoshima, T., Zjawiony, J. K: Marine Drugs, 1, 1-7 (2004).
  44. Synthesis of 3,5-Dibromo-O-methyl-L-tyrosine. Stewart, J. Katsuyama, I., Fahmy, H., Fronczek, F.R., Zjawiony, J. K.: A Direct Synthetic Communications, 34(3), 531-539 (2004).
  45. Design and Synthesis of Some Substituted 1H-pyrazolyl thiazolo[4,5-d]pyrimidines as Anti-inflammatory-Antimicrobial Agents. Bekhit, A.A., Fahmy, H., Rostom, S.A., Baraka, A.: European Journal of Medicinal Chemistry 38(1), 27-36 (2003).
  46. Synthesis and in-vitro Anti-HIV Screening of Certain 2-(benzoxazol-2-ylamino)-3H-4-oxopyrimidines. Rostom, S.A., Fahmy, H., Saudi, M.N.: Scientia Phatmaceutica, 71(2), 57-74 (2003).
  47. Synthesis of 2-(4-Biphenylyl)-quinoline-4-carboxylate and carboxamide Analogs. New Human Neurokinin- 3(hNM-3) Receptor Antagonists. Saudi, M. N., Rostom, S. F., Fahmy, H., El Ashmaway, I. M.: Arch. Pharm. Pharm. Med. Chem. (Weinheim) 336(3), 165-174 (2003).
  48. Synthesis and in-vitro Evaluation of The Anticancer Activity of Novel Fluorinated Thiazolo[4,5-d]pyrimidines. Arch. Pharm. Fahmy, H., Rostom, S.A., Saudi, M.N., Zjawiony, J.K., Robins, D.J.: Pharm. Med. Chem. (Weinheim) 336(4-5), 216-225(2003).
  49. Design and Synthesis of Some Substituted 1H-Pyrazolyl-Oxazolidines or 1H-Pyrazolyl-Thiazolidines as Anti-inflammatory-Antimicrobial agents. Bekhit, A., Fahmy, H.:Arch. Pharm. Pharm. Med. Chem. (Weinheim), 336(2), 111-118 (2003).
  50. Synthesese of cis- and trans-7-chloro-7,8,9,10-tetrahydrobenzo[a]pyren-8-ol: Remarkable Solvent Effect on Epoxide Hydrochlorination Diastereoselectivity. Mahindaratne, M., Fahmy, H., Garcia, J.A., Negrete, G.R.: Synthetic Commuincation, 33(8), 1391-1398 (2003).
  51. A Semi-synthetic Analog of the Cembranoid Sarcophine. Fahmy, H., Zjawiony, J.K., Khalifa, S., Fronczek, F.R.: Acta Cryst. C59, 85-87 (2003).
  52. Semisynthesis of New Sarcophine Derivatives With Chemopreventive Activity. Katsuyama, I., Fahmy, H., Zjawiony, J.K., Zjaiowny, J.K., Khalifa, S.I., Kilada, R.W, Konoshima, T., Takasaki, M. and Tokuda, H.: Journal of Natural Products, 65, 1808-1814 (2002).
  53. Synthesis of Some New Bis-thiazoles As Possible Anticancer Agents. Fahmy, H., Bekhit, A. A.: Pharmazie, 57(12), 800-803 (2002).
  54. Synthesis and Antitumor Evaluation of New Polysubstituted Thiazole and Derived Thiazolo[4,5-d]pyrimidine Systems. Fahmy, H., Rostom, S.A., Bekhit, A.A.: Arch. Pharm. Pharm. Med. Chem. (Weinheim) 335(5), 213-222 (2002).
  55. Synthesis of Some New Triazoles as Potential Antifungal Agents. Fahmy, H.: Bollitino Chemico Pharmaceutico, 140, 423-427 (2001).
  56. Synthesis and Antimicrobial Screening of Some Novel Thiazoles, Dithiazoles and Thiazolylpyridines. Fahmy, H.: Pharmazie, 52(10), 750-753 (1997).
  57. Synthesis and Antimicrobial Activity of Rhodanine Derivatives. Habib, N.S., Rida, S.M., Badawey, E.A., Fahmy, H.T., Ghozlan, H.A.: European Journal of Medicinal Chemistry, 32(9), 759-762 (1997).
  58. Synthesis and Biological Investigations of Novel Thiazolyl-benzimidazoles and Benzimidazolyl-thiazlo[4,5-d]pyrimidines. Habibi, N.S., Rida, S.M., Badawey, E.A., Fahmy, H.T., Ghozlan, H.A.: Pharmazie, 52(5), 346-350 (1997).
  59. Synthesis of Novel Thiazolo[4,5-d]pyrimidines Derivatives for Antimicrobial, Anti-HIV, and Anticancer Investigation. Habib, N.S., Rida, S.M., Badawey, E.A., Fahmy, H.T., Ghozlan, H.A.: Pharmazie, 51(12), 927-931 (1996).
  60. Condensed Thiazoles:I. Synthesis of 5,7-Disubstituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents. Habib, N.S., Rida, S.M., Badawey, E.A., Fahmy, H.T.: Monatsh Chemie, 127(11), 1203-1207 (1996).
  61. Condensed Thiazoles: II. Synthesis of 7-Substituted Thiazolo[4,5-d]pyrimidines as Possible Anti-HIV, Anticancer, and Antimicrobial Agents. Rida, S.M., Habib, N.S., Badawey, E.A., Fahmy, H.T.: Monatsh Chemie, 127(11), 1209-1214 (1996).
  62. Synthesis of Some Novel Perhydrotriazepine-3,6-diones of Potential Antifungal Activity. Mahran, M.A., El-Sayed, O.A., Fahmy, H.T., Ashour, F.A.: Alexandria journal of pharmaceutical sciences, 10(2), 133-135 (1996).
  63. Synthesis and Biological Investigations of Some New Thiazolyl-benzimidazoles and Benzimidazolyl-thiazolo[3,2-a]pyridines. Rida, S.M., Habib, N.S., Badawey, E.A., Fahmy, H.T., Ghozlan, H.A.: Arch. Pharm. (Weinheim), 328(4), 325-328 (1995).
  64. Potential Antimicrobials I. Synthesis and Structure-Activity Studies of Some New Thiazolo[4,5-d]pyrimidine Derivatives.Badawey, E.A., Rida, S.M., Hazza, A.A., Fahmy, H.T., Gohar, Y.M.: European Journal of Medicinal Chemistry, 28(2), 91-96 (1993).
  65. Potential Antimicrobials II. Synthesis and In-Vitro Anti-Microbial Evaluation of Some New Thiazolo[4,5-d]pyrimidine Derivatives. Badawey, E.A., Rida, S.M., Hazza, A.A., Fahmy, H.T., Gohar, Y.M.: European Journal of Medicinal Chemistry, 28(2), 97-101 (1993).
  66. Assesment of Anti-HIVActivity of Some Benzimidazolyl-thiazoles. Badawey, E.A., Hazza, A.A., Rida, S.M., Fahmy, H.T.: Arch. Pharm. (Weinheim), 325(9), 565-567 (1992).
Mailing Address:
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Pharmaceutical Sciences-Box 2202C
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Brookings, SD 57007
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